Peripheral alpha-synuclein levels in patients with genetic and non-genetic forms of Parkinson's disease |
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| Affiliation: | 1. Department of Psychiatry & Behavioral Science (MI, HB, HM, TI, SY, HS, TS, HA), Juntendo University Graduate School of Medicine, Tokyo, Japan;2. the Juntendo University Mood Disorder Project (HB, HM, TS, MI, HS, TS), Department of Psychiatry, Juntendo Koshigaya Hospital, Saitama, Japan;1. College of Pharmacy, Ferris State University, Big Rapids, MI, USA;2. Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA |
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| Abstract: | BackgroundVariations of α-synuclein levels have been reported in serum and plasma in Parkinson's Disease (PD) Patients.MethodsSerum and plasma were obtained from PD patients without known mutations (GU-PD, n = 124)), carriers of the A53T/G209A point mutation in the α-synuclein gene (SNCA) (n = 29), and respective age-/sex-matched controls. Levels of total α-synuclein were assessed using an in-house ELISA assay.ResultsA statistically significant increase of α-synuclein levels was found in serum, but not plasma, from GU-PD patients compared to healthy controls. A statistically significant decrease of α-synuclein levels was found in serum and plasma from symptomatic A53T mutation carriers compared to healthy controls. Plasma α-synuclein levels were modestly negatively correlated with UPDRS part III score and disease duration in A53T-PD patients.ConclusionIncreased α-synuclein levels in serum of GU-PD patients suggest a systemic deregulation of α-synuclein homeostasis in PD. The opposite results in A53T-PD highlight the complexity of α-synuclein homeostatic regulation in PD, and suggest the possibility of reduced expression of the mutant allele. |
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| Keywords: | Parkinson disease Alpha-synuclein Plasma Serum A53T |
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