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Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson's disease--a rCBF scintigraphy study
Authors:Wallin A  Ekberg S  Lind K  Milos V  Granérus A-K  Granerus G
Affiliation:Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden;
Division of Clinical Physiology, Section of Nuclear Medicine, IMV, Linköping University, Linköping, Sweden;
Department of Neuroscience and Locomotion, Division of Geriatrics, Linköping University, Linköping, Sweden
Abstract:Objectives –  The aim of the study was to visualize cortical function in Parkinson's patients with various degrees of cognitive impairment.
Materials and methods –  Thirty-seven patients with Parkinson's disease and three with Parkinson plus syndromes underwent cognitive assessment and rCBF using 99mTC-HMPAO-SPECT.
Results –  Almost no regional reductions in cerebral blood flow were seen in patients without cognitive impairment ( n  = 16). Limited, mainly posterior, blood flow reductions were seen in patients with mild cognitive impairment ( n  = 14), whereas the reductions were extensive and bilaterally symmetric, involving both anterior and posterior brain regions in patients with dementia ( n  = 10).
Conclusions –  The findings suggest a widespread cortical, mainly posterior type of dysfunction and a relationship between the degree of cognitive impairment and the magnitude of the dysfunction.
Keywords:Parkinson's disease  cognitive impairment  SPECT  blood flow  Alzheimer's disease
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