Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson's disease--a rCBF scintigraphy study |
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Authors: | Wallin A Ekberg S Lind K Milos V Granérus A-K Granerus G |
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Affiliation: | Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden; Division of Clinical Physiology, Section of Nuclear Medicine, IMV, Linköping University, Linköping, Sweden; Department of Neuroscience and Locomotion, Division of Geriatrics, Linköping University, Linköping, Sweden |
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Abstract: | Objectives – The aim of the study was to visualize cortical function in Parkinson's patients with various degrees of cognitive impairment. Materials and methods – Thirty-seven patients with Parkinson's disease and three with Parkinson plus syndromes underwent cognitive assessment and rCBF using 99mTC-HMPAO-SPECT. Results – Almost no regional reductions in cerebral blood flow were seen in patients without cognitive impairment ( n = 16). Limited, mainly posterior, blood flow reductions were seen in patients with mild cognitive impairment ( n = 14), whereas the reductions were extensive and bilaterally symmetric, involving both anterior and posterior brain regions in patients with dementia ( n = 10). Conclusions – The findings suggest a widespread cortical, mainly posterior type of dysfunction and a relationship between the degree of cognitive impairment and the magnitude of the dysfunction. |
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Keywords: | Parkinson's disease cognitive impairment SPECT blood flow Alzheimer's disease |
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