The effect of currently available contact lens disinfection systems on Acanthamoeba castellanii and Acanthamoeba polyphaga   总被引：6，自引：0，他引：6  

R E Silvany  J M Dougherty  J P McCulley  T S Wood  R W Bowman  M B Moore 《Ophthalmology》1990,97(3):286-290

Contact lens disinfection systems were evaluated for their effectiveness in killing Acanthamoeba castellanii and Acanthamoeba polyphaga trophozoites and cysts. Amoebae were inoculated into commercially available contact lens cleaning and soaking solutions. At intervals varying from 30 minutes to 24 hours, solutions were filtered. The filters were removed and cultured for Acanthamoeba organisms. Striking differences were observed in the abilities of the different disinfecting solutions to kill the organisms. Solutions containing chlorhexidine were effective at very short exposure times. Solutions containing benzalkonium chloride required slightly longer exposure times but were faster than solutions containing only thimerosal. Solutions containing sorbate, polyaminopropyl biguanide, or polyquaternium-1 were not effective at killing Acanthamoeba organisms in the time allotted for the experiment. Solutions containing hydrogen peroxide were quite effective if the agent was not prematurely catalyzed. A. polyphaga generally required longer exposure to disinfectants than did A. castellanii for complete inhibition to occur.  相似文献   

Adenoviral acute hemorrhagic cystitis following renal transplantation   总被引：3，自引：0，他引：3  

W Buchanan  J S Bowman  G Jaffers 《American journal of nephrology》1990,10(4):350-351

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Levels of prostate specific antigen that predict skeletal spread in prostate cancer.     

M L Pantelides  S P Bowman  N J George 《British journal of urology》1992,70(3):299-303

The ability of serum prostate specific antigen (PSA) and serum acid phosphatase (SAP) to identify skeletal spread was evaluated in untreated patients with prostatic cancer. Twenty patients with scintigraphic evidence of metastatic disease in bone (M1) at diagnosis were compared with 50 untreated patients in whom scans were repeatedly negative during long-term surveillance. Using the present laboratory upper limit of normal (ULN) of 3 iu/l, the sensitivity and specificity of SAP for M1 disease were 80 and 86% respectively. Stepwise discriminant analysis demonstrated that SAP was able to stage patients correctly (bone scan positive or negative) with 81% predictive accuracy at an optimum cut-off limit of 4.6 iu/l. By contrast, whilst PSA (Hybritech) was 100% sensitive for skeletal disease at 10 ng/ml--at the expense of poor (36%) specificity--analysis determined that an optimum cut-off limit of 58 ng/ml led to 79% predictive accuracy for disease in bone. It was concluded that PSA levels > 58 ng/ml are highly indicative of spread to the skeleton, even in the absence of radiological or scintigraphic evidence of metastases.  相似文献   

The proliferation and differentiation of the bone-lining cell in estrogen-induced osteogenesis   总被引：1，自引：0，他引：1  

B M Bowman  S C Miller 《BONE》1986,7(5):351-357

The purpose of this study was to determine the capacity of the bone-lining cell, which covers most nonremodeling bone surfaces in the adult skeleton, to proliferate and contribute to the rapid endosteal osteogenic response following estrogen treatment in male Japanese quail. In control, untreated birds bone-lining cells cover most of the femoral endosteal surface. Bone-lining cells are thinly extended along bone surfaces, have flat nuclei, and account for about 77% of the cells adjacent to the bone surface. The lineal density of bone surface cells in the controls was about 21 cells/mm of bone surface. By 16-20 h after estrogen administration cells with larger, round nuclei were seen on the bone surface and some of these cells contained a 3H-thymidine (3H-TdR) label. Within the first 24 h after estrogen administration the lineal bone surface cell density had increased to about 38 cells/mm. At 20-30 h after estrogen administration, most of the cells adjacent to the bone surface were round. The peak 3H-TdR labeling of cells immediately adjacent to the bone surface occurred about 36 h after estrogen administration. By 48 h the bone surface was covered with osteogenic cells and developing medullary bone. These results suggest that the bone-lining cell in the adult appears to retain some proliferative capability and osteogenic potential. However, because a rapid increase in cell density began prior to the rapid increases in 3H-TdR labeling, as well as the appearance of mitotic figures on the bone surface, another source of cells may have also contributed to the osteogenic response induced by estrogen.  相似文献   

Traumatic rupture of extracardiac valved conduit: unusual late complication producing outflow tract obstruction     

P C Ursell  S P Griffiths  F O Bowman 《The Annals of thoracic surgery》1988,46(3):351-352

A 22-year-old woman died suddenly 15 years after successful repair of truncus arteriosus with a valved Dacron conduit. At autopsy there was complete obstruction of the right ventricular outflow tract by a large organizing thrombus between the outer aspect of the conduit and the adherent pericardial tissue. This rare late complication may have resulted from an unrecognized deceleration injury occurring at the time of a serious automobile accident 5 months before death.  相似文献   

Cultural considerations for Canadians in the diagnosis of brain death     

Kerry W. Bowman  Shawn A. Richard 《Journal canadien d'anesthésie》2004,51(3):273-275

PURPOSE: This articles explores cultural perceptions and values related to brain death and organ donation from both a Western and non-Western perspective. SOURCE: Anthropological literature review of the historical concept of brain death in Canada using Eastern culture as a comparison. Principal findings: Although the concept of brain death and concomitant organ donation have become widely practiced in Western nations such as Canada, from a cross-cultural point of view these concepts and practices can be deeply troubling and may hold profoundly different meaning to people new to Canada. CONCLUSIONS: Canada has a deep commitment and obligation to respect diversity as reflected in the Canadian Charter of Rights and Freedoms. Therefore, healthcare workers have an obligation to respect cultural differences. To truly respect cultural differences we must first explore our own culturally formulated belief systems and then consider how our views may interface with other cultures. Our findings call for a greater analysis of the cultural influences on the concept of brain death and organ donation as a means of building a better understanding and respect for cultural diversity.  相似文献   

Human transferrin: expression of chimeric genes in transgenic mice     

G S Adrian  D C Herbert  L K Robinson  E K Adrian  C A Walter  F J Weaker  F Yang  B H Bowman 《Current studies in hematology and blood transfusion》1991,(58):104-108

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Americans have a shared vision: occupational therapists can help create the future reality.     

O J Bowman 《The American journal of occupational therapy》1992,46(5):391-394

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The health of the novelist and printer Samuel Richardson (1689-1761): a correlation of documentary and skeletal evidence.          下载免费PDF全文

J L Scheuer  J E Bowman 《Journal of the Royal Society of Medicine》1994,87(6):352-355

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Meeting the Challenges of Workload and Building a Practice: The Perspectives of 10 Rural Physicians     

R C Bowman  B F Crabtree  J B Petzel  T S Hadley 《The Journal of rural health》1997,13(1):71-77

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