Effects of growth hormone on glucose and fat metabolism in human subjects.     

Jens O L J?rgensen  Louise M?ller  Morten Krag  Nils Billestrup  Jens S Christiansen 《Endocrinology & Metabolism Clinics of North America》2007,36(1):75-87

This article focuses on in vivo data from tests performed in normal subjects and in patients who had abnormal growth hormone (GH) status. Experimental data in human subjects demonstrate that GH acutely inhibits glucose disposal in skeletal muscle. At the same time GH stimulates the turnover and oxidation of free fatty acid (FFA), and experimental evidence suggests a causal link between elevated FFA levels and insulin resistance in skeletal muscle. Observational data in GH-deficient adults do not indicate that GH replacement is associated with significant impairment of glucose tolerance, but it is recommended that overdosing be avoided and glycemic control be monitored.  相似文献   

Migratory, invasive and metastatic capacity of NCAM transfected rat glioma cells     

Klaus Edvardsen  Nils Brünner  Mogens Spang-Thomsen  Frank S. Walsh  Elisabeth Bock 《International journal of developmental neuroscience》1993,11(5)

A cDNA encoding a transmembrane 140 kDa isoform of the neural cell adhesion molecule, NCAM, was transfected into the rat glioma cell line BT4Cn. Transfectants with a homogeneously high expression of NCAM-B showed a decreased capacity for penetration of an artificial basement membrane when compared to cells transfected with expression-vector alone or untransfected cells. However, when injected subcutaneously into nude mice, both NCAM expressing cells and control cells produced invasive tumors. Nude mice injected with NCAM positive cells developed tumors with slower growth rates as compared to those induced by NCAM negative cells. This implies that NCAM may not only be involved in adhesive and motile behaviour of glioma cells, but also in their growth regulation.  相似文献   

Epidemiologie und Prävention von AIDS in der Bevölkerung     

Somaini  Bertino  Billo  Nils  Dubois  Jean-Alain  Staub  Roger 《International journal of public health》1988,33(7):340-344

International Journal of Public Health - Die Übertragungswege des HIV, welche in der Bevölkerung eine Rolle spielen, sind heute bekannt. Neben der sexuellen Übertragung, der...  相似文献   

Wear of the Christiansen hip prosthesis     

Leif Ivar Havelin  Nils Roar Gjerdet  Ole Dankert Lunde  Milan Rait  Einar Sudmann 《Acta orthopaedica》1986,57(5):419-422

The wear was examined in 39 Christiansen total hip prostheses, which were removed because of mechanical loosening after being used 5 (3-11) years. In the polyacetal acetabular cups, the head had made an eccentric defect, the mean volume of which was 680 (180-3310) mm³. The mean penetration of the head into the wall of the cup was 0.8 (0.1-3.2) mm. In two additional cups the head had penetrated right through the wall of the cup. In three prostheses the polyacetal sleeve of the trunnion was so worn that the head bore directly on the stem. There was a positive correlation between wear and the time the prostheses had been used before symptoms of loosening presented.  相似文献   

Leucocyte and platelet derived bioactive substances in stored standard platelet concentrates     

Lisbeth Edvardsen  Hans Jrgen Nielsen  Anders Navrsted Pedersen  Esben Dybkjr  Claus Michael Reimert  Jrgen Jesper Hvolris  Nils Brünner 《European journal of haematology》1996,57(2):185-187

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Development and Evaluation of a Skin Organ Model for the Analysis of Radiation Effects     

Dr. Dr. habil. Viktor Meineke MD  Kerstin Müller  Roland Ridi  Nils Cordes  Frank-Michael Köhn  Artur Mayerhofer  Johannes Ring  Dirk van Beuningen 《Strahlentherapie und Onkologie》2004,180(2):102-108

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Physical activity is associated with a low prevalence of musculoskeletal disorders in the Royal Norwegian Navy: a cross sectional study     

Tone Morken  Nils Magerøy  Bente E Moen 《BMC musculoskeletal disorders》2007,8(1):56

Background  

Despite considerable knowledge about musculoskeletal disorders (MSD) and physical, psychosocial and individual risk factors there is limited knowledge about physical activity as a factor in preventing MSD. In addition, studies of physical activity are often limited to either leisure activity or physical activity at work. Studies among military personnel on the association between physical activity at work and at leisure and MSD are lacking. This study was conducted to find the prevalence of MSD among personnel in the Royal Norwegian Navy and to assess the association between physical activity at work and at leisure and MSD.  相似文献   

Correction: Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study     

Nils G Morgenthaler  Joachim Struck  Mirjam Christ-Crain  Andreas Bergmann  Beat Müller 《Critical care (London, England)》2004,9(2):169

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Severe Neurological Complications after Central Neuraxial Blockades in Sweden 1990-1999   总被引：3，自引：0，他引：3  

Moen  Vibeke M.D.; Dahlgren  Nils M.D.  Ph.D.&#x;; Irestedt  Lars M.D.  Ph.D.&#x; 《Anesthesiology》2004,101(4):950-959

Background: Central neuraxial blockades find widespread applications. Severe complications are believed to be extremely rare, but the incidence is probably underestimated.

Methods: A retrospective study of severe neurologic complications after central neuraxial blockades in Sweden 1990-1999 was performed. Information was obtained from a postal survey and administrative files in the health care system. During the study period approximately 1,260,000 spinal blockades and 450,000 epidural blockades were administered, including 200,000 epidural blockades for pain relief in labor.

Results: The 127 complications found included spinal hematoma (33), cauda equina syndrome (32), meningitis (29), epidural abscess (13), and miscellaneous (20). Permanent neurologic damage was observed in 85 patients. Incidence of complications after spinal blockade was within 1:20-30,000 in all patient groups. Incidence after obstetric epidural blockade was 1:25,000; in the remaining patients it was 1:3600 (P < 0.0001). Spinal hematoma after obstetric epidural blockade carried the incidence 1:200,000, significantly lower than the incidence 1:3,600 females subject to knee arthroplasty (P < 0.0001).  相似文献   

Comparison of some salivary variables between vegetarians and omnivores     

Gunnar Johansson  Nils Ravald 《European journal of oral sciences》1995,103(2):95-98

The aim of the study was to compare salivary variables in a group of vegetarians with a group of omnivores. Twenty-nine vegetarians, 19 women and 10 men, mean age 35 yr, and 28 omnivores, 20 women and 8 men, mean age 35 yr, were compared in terms of salivary secretion rate, pH, buffer capacity, mutans streptococci and lactobacilli. The vegetarians had a significantly higher secretion rate, but there were no other significant differences regarding the salivary variables. The difference in secretion rate may have been caused by some lifestyle factor(s) differing between vegetarians and omnivores which probably mainly include nutrient(s), texture and roughness of the food.  相似文献