Heredity and Visual Development     

Sheffield JB  Hilfer SR 《Clinical & experimental optometry》1987,70(4):133-133

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Immediate repair of urethroperineal fistulas after abdominoperineal amputation by means of a cutaneo-muscular flap of the gluteus maximus. Apropos of 2 successfully treated cases     

A Avril  A Faucher  P Mage  D Marée  P Lamarche  J L Renaud-Salis 《Journal de chirurgie》1986,123(10):582-585

Although a rare complication, the development of a urethro-perineal urinary fistula immediately after abdomino-perineal amputation is a difficult problem to solve. The fragility of the membranous urethra immediately in contact with the exenterated pelvic cavity which takes several weeks to fill in makes any attempt at isolated direct suture very hazardous. Secondary repair is also frequently difficult and the "functional prognosis is far from being always favourable". The major handicap resulting from the perpetuation of this type of fistula has led us to propose an attempt at immediate repair as soon as it is diagnosed with filling of the pelvi-perineal cavity by a cutaneo-muscular flap taken from gluteus maximus. In the two cases in which this treatment was performed, the fistula was cured and a good quality functional result was obtained.  相似文献   

Evaluation and management of atherogenic dyslipidemia: beyond low-density lipoprotein cholesterol   总被引：1，自引：1，他引：0       下载免费PDF全文

Jean-Pierre Desprs  Isabelle Lemieux  Gilles R. Dagenais  Bernard Cantin    BenoÎt Lamarche 《Canadian Medical Association journal》2001,165(10):1331-1333

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Intermittent claudication: From its risk factors to its long-term prognosis in men. The Quebec Cardiovascular Study     

Annie C. St-Pierre  Bernard Cantin  Benoît Lamarche  Dominique Auger  Jean-Pierre Després  Gilles R. Dagenais 《The Canadian journal of cardiology》2010,26(1):17-21

BACKGROUND:

The natural history of intermittent claudication, from its risk factors to its cardiovascular prognosis, has been reported in few prospective studies.

OBJECTIVE:

To assess incident intermittent claudication, as well as its risk factors and long-term prognosis in men.

METHODS:

A random sample of 4376 men 35 to 64 years of age from Quebec City (Quebec), who were free of cardiovascular disease (CVD), was evaluated in 1974 for CVD risk factors and followed until 1998. To assess the prognosis, the event rates between 1985 and 1998 were computed among men with incident claudication without other CVD, incident survivors of a first myocardial infarction (MI) without other CVD and men free of CVD between 1974 and 1985.

RESULTS:

From 1974 to 1998, 300 men developed intermittent claudication. Tobacco consumption, high systolic blood pressure and diabetes at least doubled the adjusted RR (aRR) of intermittent claudication. In 1985, there were 80 claudicants, 2868 men free of CVD and 68 survivors of a first MI. During the 13-year follow-up, a new CVD occurred in 48.8% of the claudicants, in 18.9% of men without CVD (aRR 2.08; 95% CI 1.48 to 2.90) and in 45.6% of MI survivors (aRR compared with claudicants 1.12; 95% CI 0.69 to 1.79). There was also no significant difference between claudicants and MI survivors for fatal CVD, nonfatal CVD and total mortality.

CONCLUSIONS:

Men with intermittent claudication are at high risk for CVD that may be equivalent to men with previous MI.  相似文献   

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies   总被引：7，自引：1，他引：7  

Dahia  PL; Aguiar  RC; Alberta  J; Kum  JB; Caron  S; Sill  H; Marsh  DJ; Ritz  J; Freedman  A; Stiles  C; Eng  C 《Human molecular genetics》1999,8(2):185-193

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Sperm quality in Hodgkin's disease versus non-Hodgkin's lymphoma   总被引：3，自引：4，他引：3  

Botchan  A; Hauser  R; Gamzu  R; Yogev  L; Lessing  JB; Paz  G; Yavetz  H 《Human reproduction (Oxford, England)》1997,12(1):73-76

The study was conducted to determine the deleterious effect of lymphoma disease on spermatogenesis and to evaluate the possibility that the disease is mediated primarily by inherent mechanisms in Hodgkin's disease and non-Hodgkin's lymphoma patients. A total of 89 patients with lymphoma disease (Hodgkin's and non-Hodgkin's) were referred for sperm preservation prior to adjuvant treatments. A comparison was made of pre- and post-thaw sperm quality between lymphoma patients and healthy volunteers who applied for sperm donation. This was followed by further assessment of the differences between patients with Hodgkin's disease and non-Hodgkin's lymphoma in terms of sperm variables, clinical parameters and blood hormone concentrations. It was found that patients with lymphoma disease had significantly impaired pre-freeze and post-thaw sperm quality compared with that of healthy volunteers. Patients with non-Hodgkin's lymphoma had spermatozoa of higher quality than patients with Hodgkin's disease. No differences were found in the clinical or hormonal parameters between these two groups. As expected, reduced testicular size and abnormal testicular consistency were correlated with decreased sperm quality. The mere presence of cancer disease has a direct negative effect on spermatogenesis, which is probably not related to incidental side-effects. A variable degree of impairment should be expected with different categories of cancer.   相似文献   

Including emergency and acute care as a global health priority     

Nicholas Risko  Emilie JB Calvello  Sarah Stewart de Ramirez  Mayur Narayan  Jon Mark Hirshon 《International journal of emergency medicine》2011,4(1):1-2

The clinical findings of Takatsubo Cardiomyopathy and acute myocardial infarction can be very similar. While Takatsubo cardiomyopathy rarely leads to severe complications, acute myocardial infarction can be life threatening. Treatment of both these conditions is different and so it is imperative for clinicians to have a high index of suspicion for either. Several EKG differences between the two entities have been proposed. This article summarizes the EKG changes most likely seen in Takatsubo cardiomyopathy and compares them to those seen in Acute Myocardial infarction.  相似文献   

Effect of the Mediterranean diet on plasma adipokine concentrations in men with metabolic syndrome     

Caroline Richard  Marie-Michelle Royer  Patrick Couture  Katherine Cianflone  Reza Rezvani  Sophie Desroches  Benoît Lamarche 《Metabolism: clinical and experimental》2013,62(12):1803-1810

ObjectiveWhile a Mediterranean dietary pattern (MedDiet) has been associated with favorable changes in several features of metabolic syndrome (MetS), its impact on plasma adipokine concentrations remains largely unknown. The objective of this study was to determine the impact of the MedDiet consumed under controlled feeding conditions, without (? WL) and with weight loss (+ WL), on plasma adipokine concentrations in adult men with MetS (NCEP-ATP III).Materials/MethodsThe diet of 26 men with MetS (age 24 to 62 yrs) was first standardized to a North American control diet for 5 weeks. Participants then consumed a pre-determined MedDiet for 5 weeks. Both diets were consumed under weight-maintaining isoenergetic feeding conditions. Participants then underwent a 20-week free-living caloric restriction period, after which they consumed the MedDiet again in weight stabilizing, isoenergetic feeding conditions.ResultsBody weight was reduced by 10.2% ± 2.9% and waist circumference by 8.6 ± 3.3 cm after the weight loss period and stabilization on MedDiet (P < 0.001). MedDiet ? WL had no impact on plasma concentrations of leptin, plasminogen activator inhibitor-1, resistin, visfatin, acylation stimulating protein and adiponectin. MedDiet + WL reduced plasma leptin concentrations (P < 0.01) and increased plasma adiponectin concentrations (P < 0.05) compared with the control diet and MedDiet ? WL.ConclusionData from this nutritionally controlled study suggest that short-term consumption of MedDiet has little effect on the concentrations of many adipokines in the absence of weight loss.  相似文献   

Plasma metabolism of apoB-containing lipoproteins in patients with hepatic lipase deficiency   总被引：2，自引：0，他引：2  

Ruel IL  Couture P  Cohn JS  Lamarche B 《Atherosclerosis》2005,180(2):355-366

The metabolism of apoB-containing lipoproteins was investigated in the fasted state in three complete and three partial hepatic lipase (HL)-deficient subjects as well as in seven normotriglyceridemic (NTG) and two hypertriglyceridemic (HTG) controls using a 12 h primed-constant infusion of l-[5,5,5-d₃]-leucine. Two males with complete HL deficiency had increased plasma pool sizes of VLDL and IDL apoB-100 due to substantial reductions in fractional catabolic rate (FCR) of VLDL and IDL apoB-100 compared with both NTG and HTG controls. Reductions in LDL apoB-100 production rate (PR) were also observed in these two patients compared with NTG and HTG controls. Complete HL deficiency in the female proband was associated with normal VLDL apoB-100 kinetics, while plasma IDL apoB-100 pool size was increased by 124% due to an 82% decrease in the FCR of IDL apoB-100. The FCR and PR of LDL apoB-100 were reduced by 64 and 51%, respectively, in the proband compared with sex-matched controls. Partial HL-deficient patients were characterized by apoB-containing lipoprotein metabolism similar to that of controls. These results indicate that complete HL deficiency is associated with a potentially atherogenic apoB-containing lipoprotein metabolism that can be modulated considerably by secondary factors such as gender and abdominal obesity.  相似文献   

蛋白质组学及其相关技术在运动人体科学中的应用   总被引：1，自引：0，他引：1  

马巍然  柯杰兵 《中国组织工程研究与临床康复》2007,11(23):4618-4621

目的:对蛋白组学及蛋白芯片技术发展现状进行综述,为该技术在运动医学中的应用提供参考资料。资料来源:应用计算机检索PubMed2003-01/2006-12期间相关蛋白组学及蛋白芯片技术方面的文章,检索词“exercise AND protein chip,protein microarray”,并限定文章语言种类为English。同时计算机检索万方数据库2003-01/2006-12期间相关蛋白组学及蛋白芯片技术方面的文章,检索词“蛋白质,运动锻炼,运动医学”,并限定文章语言种类为中文。资料选择:对资料进行初审,并查看每篇文献后的引文。纳入标准:文章所述内容应与蛋白质组学及蛋白质芯片技术的研究相关。排除标准:重复研究或Meta分析类文章。资料提炼:共收集到312篇相关文献,32篇文献符合纳入标准,排除的280篇文献为内容陈旧或重复。资料综合:蛋白组学研究已成为基因组学研究后生命科学发展的大方向之一。它研究的主要内容包括:蛋白质分离与鉴定、蛋白质功能的确定、蛋白质翻译后修饰及相互作用、各种疾病或疲劳标志物的筛选与疾病诊断、生物信息学及药物开发等方面。文章在对蛋白质组学的发展及其相关技术在运动人体科学中的应用现状进行综述的基础上,对运动人体科学未来的发展方向进行了展望。由于蛋白质组学的建立以及蛋白质芯片技术的逐步完善,对运动人体科学的研究及其发展将起到很好的促进作用。结论:未来将从分子水平上阐明运动与人体适应的分子生物学机制,研究热点将集中于从运动营养蛋白质组学、反兴奋剂的蛋白质芯片技术、运动员机能评定的蛋白质芯片研究等方面。  相似文献