The laryngeal mask airway and intra-ocular surgery     

R. Holden  D. Morsman  J. Butler  G. Clarke 《Anaesthesia》1992,47(5):446-446

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Interventional radiology for restoration of vascular patency in the postoperative patient--case reports     

J T Mail  G J Becker  R W Holden  H Y Yune 《Angiology》1987,38(12):903-911

The postoperative patient may present with one or more of a variety of problems amenable to management by interventional radiologic techniques, which may be curative by themselves or may, in addition, require or allow successful surgical intervention. To optimize patient care, a good working relationship between the vascular surgeon and the interventional radiologist is essential. Consideration should be given to the patient's presenting signs and symptoms, the surgical history with its alteration of anatomy, the results of available noninvasive studies, and knowledge of various therapeutic alternatives. Vascular radiologic interventions include angioplasty, thrombolytic therapy, a combination of both angioplasty and thrombolysis, and newer techniques such as percutaneous valvectomy. In this report, examples of some of the experience at Indiana University are presented. Emphasis is placed on the appropriate approach to the patient.  相似文献   

Over-the-counter medications. Do you know what your patients are taking?     

M D Holden 《Postgraduate medicine》1992,91(8):191-4, 199-200

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Reversible endothelial changes in the monkey cornea.     

M C Madigan  B A Holden 《Cornea》1992,11(4):319-325

As part of a study examining the effects of contact lens extended wear in monkeys (Macaca fascicularis), reversible endothelial changes were observed in the cornea with slit lamp biomicroscopy and contact specular microscopy. These changes were associated with anterior eye inflammation in four monkeys (as occurs in humans). However, in two monkeys no obvious cause for these changes other than the presence of a contact lens on the cornea was apparent. In these two monkeys the endothelium displayed features similar to the transient endothelial bleb response, which has been observed only in humans. The monkey (M fascicularis) may thus be an appropriate model for further investigation of the endothelial response during anterior eye inflammation and the transient endothelial bleb response.  相似文献   

Tear plasmin activity with contact lens wear.     

A Vannas  D F Sweeney  B A Holden  E Sapyska  E M Salonen  A Vaheri 《Current eye research》1992,11(3):243-251

Plasmin, a proteolytic enzyme, has been detected in the tears of patients experiencing anterior ocular disease, and during contact lens wear. Using a radial caseinolysis procedure, we examined tear plasmin levels in 66 patients who were wearing soft and rigid lenses for daily and extended wear. Compared to non-contact lens wearers, patients wearing soft and rigid lenses for extended wear were significantly more likely to exhibit tear plasmin activity. Eight hours of open-eye thick HEMA lens wear did not induce tear plasmin activity in a group of 10 subjects. However, significant increases in tear plasmin activity were recorded after short-term (1 hour) eye closure with and without lens wear, and following overnight (8 hours) eye closure without lens wear. Overnight eye closure also resulted in significantly increased numbers of epithelial cells and leucocytes in the tear fluid. Our results suggest that increased tear plasmin activity during extended contact lens wear may be attributable to the effects of eye closure rather than hypoxia or the presence of the contact lens per se.  相似文献   

Professor Brian Layland OAM     

Brien Holden  Kylie Evans 《Clinical & experimental optometry》2003,86(4):260-264

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Incision depth affects the recovery of corneal sensitivity and neural regeneration in the cat   总被引：2，自引：0，他引：2  

T Chang-Ling  A Vannas  B A Holden  D J O'Leary 《Investigative ophthalmology & visual science》1990,31(8):1533-1541

To assess the effect of incision depth on the recovery of corneal sensitivity and neural regeneration, adult domestic cats underwent either 8-mm circular nonpenetrating keratotomies or penetrating autografts. The contralateral eye served as control. Corneal sensitivity was determined at various intervals after surgery. The depth of incision in the nonpenetrating keratotomies, assessed by optical pachometry, ranged between 49 and 91% of total corneal thickness. The animals were ranked based on the depth of incision and the average sensitivity within the keratotomy over the 1-yr recovery period. A significant negative correlation was found between incision depth and the recovery of sensitivity (Spearman rank-order correlation r = -0.84, P less than 0.05). Some recovery of sensitivity was found in the center and periphery of the incised zone when incision depth was less than 53% of total corneal thickness. With deeper incisions, the center of the incised zone remained insensitive throughout the measurement period, while the periphery of the incised zone showed a slight recovery of corneal sensitivity, proportional to incision depth. The recovery of corneal sensitivity was higher in a small annular region just distal to the incision site. When incision depth exceeded approximately 53%, gold chloride impregnation showed that the resultant reinnervation was confined to single intraepithelial axons or localized regions of irregular epithelial fibers. With shallower incisions, the deeper stromal trunks were spared, resulting in the persistence of a reduced subepithelial plexus and basal epithelial leashes. We have shown that when an incision severs all stromal trunks, the neural regeneration is insufficient for functional recovery of corneal sensitivity at the center of an 8-mm keratotomy.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

Reply     

C.C. Harland  R.P. Whitaker  J.L. Barron  C.A. Holden 《The British journal of dermatology》1993,129(4):498-499

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Analysis of 1263 deaths in four general practices.   总被引：4，自引：0，他引：4       下载免费PDF全文

J Holden  S O'Donnell  J Brindley    L Miles 《The British journal of general practice》1998,48(432):1409-1412

BACKGROUND: The death of a patient is a significant event that occurs often enough in general practice for it to have the potential to tell us much about the care we provide. There are few large series in the literature and we still know little about the collaborative use of this outcome measure. AIM: To determine the pattern of deaths and potentially preventable factors in our practices. METHOD: We completed a standard data collection form after each death in four general practices over a 40-month period. The results were discussed at quarterly meetings. RESULTS: A total of 1263 deaths occurred among our registered patients during the period of the audit. Preventable factors contributing to deaths were considered to be attributable to: patients (40%): mainly cigarette smoking, poor compliance, and alcohol problems; general practice teams (5%): mainly delayed referral, diagnosis and treatment, and failure to prescribe aspirin to patients with vascular disease; hospitals (6%): mainly delayed diagnosis and perceived treatment problems; the environment (3%): mainly falls, principally resulting in fractured neck of femur. CONCLUSION: A simple audit of deaths along the lines that we describe gives important information about the care provided by general practice teams and those in hospital practice. It has both educational value and is a source of ideas for service improvement and further study, particularly when carried out over several years.  相似文献   

Digoxigenin-labeled probes amplified from genomic DNA detect T-cell gene rearrangements.     

J A Hopfenbeck  J A Holden  C T Wittwer  C R Kjeldsberg 《American journal of clinical pathology》1992,97(5):638-644

The detection of clonal rearrangements of the human T-cell receptor by Southern hybridization is a useful tool to diagnose morphologically difficult lymphoid proliferations. Widespread application of this method has been facilitated by the advent of sensitive nonradiolabeled probes. Although a limited number of nonradiolabeled DNA probes are commercially available, other probes must be obtained through a time-consuming and technically difficult procedure of amplification, isolation, and labeling of plasmid-cloned DNA sequences. A simple and time-saving procedure to simultaneously amplify and nonradioactively label DNA probes for use in gene rearrangement studies is described. Specifically, a method using the polymerase chain reaction to amplify and label with digoxigenin large quantities of probe to the constant region of the T-cell receptor directly from genomic DNA is described. The resultant probes are specific for the T-cell receptor-constant region, detect the appropriate germline configuration in placental DNA, and identify rearranged clonal T-cell proliferations. The polymerase chain reaction digoxigenin-labeled probes are suitable for detection by conventional colorimetric methods or by chemiluminescent detection schemes.  相似文献