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In conjunction with cartilage breakdown, muscle maladaptation including atrophy and increased fibrosis have been observed in the quadriceps following anterior cruciate ligament (ACL) injury. Previously observed upregulated muscle-related proteins in the synovial fluid following ACL rupture allude to cellular communication between the joint and muscle. Therefore, the purpose of this study was to determine whether muscle-related analytes are differentially expressed in the serum. Sixteen patients with an acute ACL tear participated in this IRB-approved study. Serum was obtained at two different time points at a mean of 6 and 14 days post-injury, and serum was analyzed by a highly multiplexed assay of 1,300 proteins. Pathway analysis using DAVID was performed; genes included met three criteria: significant change between the two study time points using a paired t test, significant change between the two study time points using a Mann–Whitney non-parametric test, and significant Benjamini post hoc analysis. Twelve analytes significantly increased between time points. Proteins chitinase-3-like protein 1 (p = 0.01), insulin-like growth factor binding protein 1 (p = 0.01), insulin-like growth factor binding protein 5 (p = 0.02), renin (p = 0.004), and lymphotoxin alpha 1: beta 2 (p = 0.03) were significantly upregulated in serum following acute ACL injury. The current results confirm the inflammatory pattern previously seen in the synovial fluid thought to play a role in the progression of post-traumatic osteoarthritis after ACL injury, and this data also provides further insights into important communication between the joint and quadriceps group, whose function is important in long term health. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:387-392, 2020  相似文献   
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目的:探讨不同呼吸机湿化管道系统在老年机械通气患者中的应用效果。方法:选取老年机械通气患者140例,随机分为3组,其中A组(n=43)使用MR410型湿化管道系统,B组(n=47)使用MR730型湿化管道系统,C组(n=50)采用MR 850型一次性双加热式、自动加水加湿湿化管道系统。观察3组湿化效果、并发症发生情况、通气时间及管道护理情况。结果:C组湿化效果适中比例最高,其次为B组,A组最低,3组间差异有统计学意义(P<0.01)。C组无导管痰痂和气道痉挛的发生,A组发生率最高,3组间差异有统计学意义(P<0.01)。C组通气时间、管道总更换次数、呼吸机管道护理时数均低于A、B组,差异有统计学意义(P<0.01)。结论:使用MR850型一次性双加热式、自动加水加湿湿化管道系统湿化效果最好,能降低并发症发生率,缩短通气时间和护理工作量。  相似文献   
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Background: Obstructive sleep apnea (OSA) has been associated with adverse fetal outcomes in some studies. Second trimester Down syndrome screening markers reflect fetal and fetoplacental wellbeing. We aimed to compare markers of fetal and feto-placental wellbeing in women with OSA and low risk controls.

Methods: A retrospective case-control study of pregnant women with OSA and available second trimester markers was performed. Controls were screened for sleep disordered breathing (SDB) at the time of delivery using a questionnaire. Women at low risk for OSA were selected. Marker levels were adjusted for gestational age and race and reported as multiples of median and later adjusted for body mass index (BMI).

Results: Twenty-four OSA cases and 166 controls were identified. Women with OSA had a higher mean BMI when compared to controls (37.1?±?12.7 versus 24.1?±?5.1, p?=?0.03). Estriol (uE3) multiples of the median (MoM) levels were lower in women with OSA compared to controls, even after adjusting for BMI, 0.74 (interquartile range (IQR) 0.45) versus 1.06 (IQR 0.38), respectively, p?=?0.026. Once adjusted for BMI, alpha feto-protein (AFP) MoM levels were no longer significantly different in women with OSA compared to controls.

Conclusion: OSA is associated with reduced serum uE3 levels, independently of BMI, possibly indicating fetal distress.  相似文献   

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目的了解男男性行为者(MSM)艾滋病预防服务覆盖现状及影响因素。方法 2013-04/10,以四川省绵阳市辖区所有9个县(市、区)MSM为对象,在固定场所经知情同意,应用滚雪球抽样法,进行调查对象招募和自填式匿名行为学调查及生物学检测。结果共调查861名,近1年接受过安全套宣传和发放/艾滋病咨询检测79.1%(681/861)、同伴教育70.7%(609/861)、做过艾滋病病毒(HIV)检测69.2%(596/861),预防服务覆盖率84.8%(727/861),不同地区差异有统计学意义(P均=0.000)。多因素分析结果,性取向同性恋、知晓艾滋病知识、酒吧/浴室/家庭型寻找性伴、认识当地MSM朋友数6人~、认识当地MSM朋友数10人、近1周肛交次数≥3、近6月肛交有保护性是MSM接受预防服务的促进因素(OR分别为2.558、10.526、4.177、2.701、5.067、4.399和2.217,P均0.05)。结论 MSM预防服务达较高水平,地区间不平衡,预防服务促进了艾滋病知识知晓和行为改变,应持续开展和加强。  相似文献   
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We describe Collinsium ciliosum from the early Cambrian Xiaoshiba Lagerstätte in South China, an armored lobopodian with a remarkable degree of limb differentiation including a pair of antenna-like appendages, six pairs of elongate setiferous limbs for suspension feeding, and nine pairs of clawed annulated legs with an anchoring function. Collinsium belongs to a highly derived clade of lobopodians within stem group Onychophora, distinguished by a substantial dorsal armature of supernumerary and biomineralized spines (Family Luolishaniidae). As demonstrated here, luolishaniids display the highest degree of limb specialization among Paleozoic lobopodians, constitute more than one-third of the overall morphological disparity of stem group Onychophora, and are substantially more disparate than crown group representatives. Despite having higher disparity and appendage complexity than other lobopodians and extant velvet worms, the specialized mode of life embodied by luolishaniids became extinct during the Early Paleozoic. Collinsium and other superarmored lobopodians exploited a unique paleoecological niche during the Cambrian explosion.Onychophorans, or velvet worms, comprise a relatively small phylum (∼180 species) of soft-bodied panarthropods constituting a minor component of modern rainforest ecosystems around the world (1). The overall organization of extant onychophorans is remarkably conserved (2), typified by a low morphological variability and homogeneous autoecologies as ambush predators of small invertebrates. An emerging fossil record, however, points to a substantially wider range of forms and habits during their early evolutionary history (38). Paleozoic lobopodians—a paraphyletic group of soft-bodied extinct organisms resembling worms with legs—occupy basal phylogenetic positions within the stem lineages of Onychophora, Tardigrada, and Euarthropoda (3, 6, 9), and thus offer critical insights about the early evolution and paleobiology of panarthropod phyla. Here, we describe the stem group onychophoran Collinsium ciliosum, a “superarmored” lobopodian with complex limbs, based on a large and exquisitely preserved population from the early Cambrian (Stage 3) Xiaoshiba Lagerstätte in South China (10, 11) (SI Appendix, Fig. S1).  相似文献   
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目的对比高黏度与低黏度骨水泥经皮椎体后凸成形术(PKP)治疗骨质疏松性椎体压缩性骨折(OVCF)的疗效差异。方法将2013年3月至2014年9月高要市人民医院收治的60例OVCF患者采用随机抽签法分为低黏度组(低黏度骨水泥PKP治疗)和高黏度组(高黏度骨水泥PKP治疗),每组各30例。对比两组手术前后伤椎椎体高度和后凸Cobb角;采用视觉模拟量表(VAS)评分、Oswestry功能障碍指数(ODI)、36项健康调查简表(SF-36)评分对患者疼痛程度、功能障碍和生活质量等主观感受进行评价;统计骨水泥渗漏、近期肺栓塞等并发症发生情况。结果低黏度组和高黏度组骨水泥注入量分别为(3.1±0.6)m L和(3.6±0.8)m L,两组比较,差异有统计学意义(P0.05)。术后随访3~6个月(平均4个月),两组术后1 d、3个月VAS评分、ODI、SF-36评分、伤椎椎体高度和后凸Cobb角均优于术前(P0.05),其中高黏度组术后1 d、3个月上述指标均优于低黏度组(P0.05)。低黏度组和高黏度组术后发生骨水泥渗漏、近期肺栓塞分别为6、2例和1、0例,两组并发症发生率比较,差异有统计学意义(P0.05)。结论与低黏度骨水泥比较,高黏度骨水泥PKP治疗OVCF近期疗效更为理想,骨水泥渗漏、近期肺栓塞等并发症发生率相对较低,值得临床推广应用。  相似文献   
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Mast cell activation disease (MCAD) is a term referring to a heterogeneous group of disorders characterized by aberrant release of variable subsets of mast cell (MC) mediators together with accumulation of either morphologically altered and immunohistochemically identifiable mutated MCs due to MC proliferation (systemic mastocytosis [SM] and MC leukemia [MCL]) or morphologically ordinary MCs due to decreased apoptosis (MC activation syndrome [MCAS] and well-differentiated SM). Clinical signs and symptoms in MCAD vary depending on disease subtype and result from excessive mediator release by MCs and, in aggressive forms, from organ failure related to MC infiltration. In most cases, treatment of MCAD is directed primarily at controlling the symptoms associated with MC mediator release. In advanced forms, such as aggressive SM and MCL, agents targeting MC proliferation such as kinase inhibitors may be provided. Targeted therapies aimed at blocking mutant protein variants and/or downstream signaling pathways are currently being developed. Other targets, such as specific surface antigens expressed on neoplastic MCs, might be considered for the development of future therapies. Since clinicians are often underprepared to evaluate, diagnose, and effectively treat this clinically heterogeneous disease, we seek to familiarize clinicians with MCAD and review current and future treatment approaches.  相似文献   
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