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1.
Danka Cholujova Gabor Beke Zachary R. Hunter Teru Hideshima Ludmila Flores Tatiana Zeleznikova Denisa Harrachova Lubos Klucar Merav Leiba Lubos Drgona Steven P. Treon Efstathios Kastritis David M. Dorfman Kenneth C. Anderson Jana Jakubikova 《International journal of cancer. Journal international du cancer》2023,152(9):1947-1963
Waldenström macroglobulinemia (WM) is a rare subtype of non-Hodgkin lymphoma characterized by malignant lymphoplasmacytic cells in the bone marrow (BM). To dissect the pathophysiology of WM, we evaluated clonal cells by mapping of B cell lymphomagenesis with adaptive and innate immune tumor microenvironment (TME) in the BM of WM patients using mass cytometry (CyTOF). In-depth immunophenotypic profiling of WM cells exhibited profound expansion of clonal cells in both unswitched and switched memory B cells and also plasma cells with aberrant expression variations. WM B lymphomagenesis was associated with reduction of most B cell precursors assessed with the same clonally restricted light chain and phenotypic changes. The immune TME was infiltrated by mature monocytes, neutrophils and adaptive T cells, preferentially subsets of effector T helper, effector CTL and effector memory CTL cells that were associated with superior overall survival (OS), in contrast to progenitors of T cells and myeloid/monocytic lineage subsets that were suppressed in WM cohort. Moreover, decrease in immature B and NKT cells was related to worse OS in WM patients. Innate and adaptive immune subsets of WM TME were modulated by immune checkpoints, including PD-1/PD-L1&PD-L2, TIGIT/PVR, CD137/CD137-L, CTLA-4, BTLA and KIR expression. The response of ibrutinib treatment to the reduction of clonal memory B cell was associated with high levels of immature B cells and effector memory CTL cells. Our study demonstrates that CyTOF technology is a powerful approach for characterizing the pathophysiology of WM at various stages, predicting patient risk and monitoring the effectiveness of treatment strategies. 相似文献
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Anderson Kelley M. Ferranti Erin P. Alagha Emily Couvillon Mykityshyn Emma French Casey E. Reilly Carolyn Miller 《Heart failure reviews》2022,27(6):2223-2249
Heart Failure Reviews - There is an expanding body of research on the bidirectional relationship of the human gut microbiome and cardiovascular disease, including heart failure (HF). Researchers... 相似文献
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Sordi Mariane B. Curtarelli Raissa B. Mantovani Iara F. Moreira Anderson C. Fernandes Celso P. Cruz Ariadne C. C. Magini Ricardo S. 《Clinical oral investigations》2022,26(3):2693-2701
Clinical Oral Investigations - This study evaluated the effect of embedding simvastatin (SIM) on the osteoinductive capacity of PLGA?+?HA/βTCP scaffolds in stem cells from human... 相似文献
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Paolo Ventura Herbert L. Bonkovsky Laurent Gouya Paula Aguilera-Peir D. Montgomery Bissell Penelope E. Stein Manisha Balwani D. Karl E. Anderson Charles Parker David J. Kuter Susana Monroy Jeeyoung Oh Bruce Ritchie John J. Ko Zhaowei Hua Marianne T. Sweetser Eliane Sardh 《Liver international》2022,42(1):i-i
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Neis Vivian B. Werle Isabel Moretti Morgana Rosa Priscila B. Camargo Anderson de O. Dalsenter Yasmim Platt Nicolle Rosado Axel F. Engel William D. de Almeida Gudrian Ricardo L. Selhorst Ingrid Dafre Alcir Luiz Rodrigues Ana Lúcia S. 《Metabolic brain disease》2022,37(5):1597-1608
Metabolic Brain Disease - Cholecalciferol deficiency has been associated with stress-related psychiatric disorders, particularly depression. Therefore, the present study investigated the... 相似文献
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Paul G. Richardson Fredrik Schjesvold Katja Weisel Philippe Moreau Larry D. Anderson Darrell White Paula Rodriguez-Otero Pieter Sonneveld Monika Engelhardt Matthew Jenner Alessandro Corso Jan Dürig Michel Pavic Morten Salomo Meral Beksac Albert Oriol Jindriska Lindsay Anna Marina Liberati Monica Galli Pawel Robak Alessandra Larocca Munci Yagci Filiz Vural Abraham S. Kanate Ruiyun Jiang Lara Grote Teresa Peluso Meletios Dimopoulos 《European journal of haematology》2022,108(1):73-83