两种除杂质工艺的爽肤洁阴洗液杀菌效果的比较   总被引：1，自引：0，他引：1  

刘峰  徐增康  张志成 《中国消毒学杂志》2003,20(1):51-53

爽肤洁阴洗液含苦参、黄柏、白头翁、生黄芪、百部、蒲公英、苍术、黄连、白癣皮、艾叶等中药,为比较两种除杂质工艺之该液的杀灭微生物效果,进行了悬液定量杀菌试验。结果,用乙醇沉淀法除杂质的爽肤洁阴洗液原液对金黄色葡萄球菌、大肠杆菌作用5 min,对白色念珠菌作用10 min,平均杀灭率均≥99.91％;用ZTCl+1澄清剂法除杂质的爽肤洁阴洗液原液对金黄色葡萄球菌作用15 min,对大肠杆菌作用20 min,平均杀灭率才≥99.92％,对白色念珠菌作用20 min的平均杀灭率仅99.84％。结果说明,用乙醇沉淀法除杂质,对该洗液中药成分杀菌效果的影响小于用ZTCl+1澄清剂处理者。  相似文献   

    

Oleg V. Merkulov  Ruslan R. Samigullin  Alexey A. Markov  Mikhail V. Patrakeev 《Materials》2021,14(20)

The electrical conductivity of La_0.5−xSr_0.5FeO_3−δ, investigated as a function of the nominal cation deficiency in the A-sublattice, x, varying from 0 to 0.02, has demonstrated a nonlinear dependence. An increase in the x value from 0 to 0.01 resulted in a considerable increase in electrical conductivity, which was shown to be attributed mainly to an increase in the mobility of the charge carriers. A combined analysis of the defect equilibrium and the charge transport in La_0.5−xSr_0.5FeO_3−δ revealed the increase in the mobility of oxygen ions, electrons, and holes by factors of ~1.5, 1.3, and 1.7, respectively. The observed effect is assumed to be conditioned by a variation in the oxide structure under the action of the cationic vacancy formation. It was found that the cation deficiency limit in La_0.5−xSr_0.5FeO_3−δ did not exceed 0.01. A small overstep of this limit was shown to result in the formation of (Sr,La)Fe₁₂O₁₉ impurity, which even in undetectable amounts reduced the conductivity of the material. The presence of (Sr,La)Fe₁₂O₁₉ impurity was revealed by X-ray diffraction on the ceramic surface after heat treatment at 1300 °C. It is most likely that the formation of traces of the liquid phase under these conditions is responsible for the impurity migration to the ceramic surface. The introduction of a cation deficiency of 0.01 into the A-sublattice of La_0.5−xSr_0.5FeO_3−δ can be recommended as an effective means to enhance both the oxygen ion and the electron conductivity and improve ceramic sinterability.  相似文献   

    

Jongwan Jung  Baegmo Son  Byungmin Kam  Yong Sang Joh  Woonyoung Jeong  Seongjae Cho  Won-Jun Lee  Sangjoon Park 《Materials》2021,14(13)

The key process steps for growing high-quality Si-based epitaxial films via reduced pressure chemical vapor deposition (RPCVD) are investigated herein. The quality of the epitaxial films is largely affected by the following steps in the epitaxy process: ex-situ cleaning, in-situ bake, and loading conditions such as the temperature and gaseous environment. With respect to ex-situ cleaning, dry cleaning is found to be more effective than wet cleaning in 1:200 dilute hydrofluoric acid (DHF), while wet cleaning in 1:30 DHF is the least effective. However, the best results of all are obtained via a combination of wet and dry cleaning. With respect to in-situ hydrogen bake in the presence of H₂ gas, the level of impurities is gradually decreased as the temperature increases from 700 °C to a maximum of 850 °C, at which no peaks of O and F are observed. Further, the addition of a hydrogen chloride (HCl) bake step after the H₂ bake results in effective in-situ bake even at temperatures as low as 700 °C. In addition, the effects of temperature and environment (vacuum or gas) at the time of loading the wafers into the process chamber are compared. Better quality epitaxial films are obtained when the samples are loaded into the process chamber at low temperature in a gaseous environment. These results indicate that the epitaxial conditions must be carefully tuned and controlled in order to achieve high-quality epitaxial growth.  相似文献   

Relationship Between Particle Size and Impurity Incorporation During Crystallization of (+)-Pseudoephedrine Hydrochloride,Acetaminophen, and Adipic Acid from Aqueous Solution     

Gu CH  Grant DJ 《Pharmaceutical research》2002,19(7):1068-1070

Pharmaceutical Research -  相似文献   

HPLC法在泊沙康唑及其15种异构体杂质拆分中的应用     

孙井龙  游凤  倪冬胜  单冰冰  赵宜香 《中国医药工业杂志》2021,(3):395-399

建立了可同时测定泊沙康唑中15种异构体(14个立体异构体和1个位置异构体)杂质的HPLC法.采用Chiral MD(2)-RH色谱柱(4.6mmx250mm,5 μm),流动相为水:乙腈∶二乙胺(48 ∶ 52 ∶ 0.1),流速为0.6 ml/min,柱温为30℃,检测波长为260 nm.结果显示,14个立体异构体以...  相似文献   

HPLC法测定比阿培南二聚物方法研究及其降解途径考察   总被引：1，自引：0，他引：1  

刘俊华  张莉  程玉宝  赫涡涛 《药物分析杂志》2012,(3):468-472

目的:建立了测定比阿培南二聚物的高效液相色谱法,同时考察二聚物的降解途径。方法:采用高效液相色谱法:色谱柱为C18柱,流动相为0.05%三氟乙酸溶液-乙腈(92∶8),检测波长为318 nm,流速为1.0 mL.min-1。结果:比阿培南溶液浓度在0.000 2～0.076 8 mg.mL-1范围内,溶液浓度与峰面积线性关系良好(r=1.000)。比阿培南二聚物A和二聚物B测定结果的重复性良好,RSD(n=6)分别为2.5%和0.8%。结论:本方法操作简便,结果可靠,可以用于比阿培南中二聚物的检测。  相似文献   

高效液相色谱电化学检测法在硫酸阿奇霉素含量测定和有关物质概况分析上的应用   总被引：2，自引：0，他引：2  

李海英  陈悦 《西北药学杂志》2003,18(4):147-149

目的　建立硫酸阿奇霉素含量测定和有关物质概况分析的 HPL C电化学检测法。方法　采用 L ichro-CART1 2 5 - 4Aluspher RP- select B柱进行分离 ;HP1 0 4 9A型安培电化学检测器检测 ;最佳检测电势 +0 .6 V;流动相为磷酸二氢钾缓冲液 -乙腈 (2 1 30∶ 870 ) ,p H 1 1 .0± 0 .1 ;流速 1 .0 m L· min-1 ;柱温 5 0℃。结果　被测样品中明显检出多个杂质峰 ;硫酸阿奇霉素主峰的峰面积与进样量在 0 .0 2～ 1 .2 μg的范围内呈良好的线性关系 ,r =0 .9997。最低检测限为 1 ng;中间精密度试验日内差为 RSD 1 .1 % ;日间差为 RSD 0 .7%。结论　本法具有较高的灵敏度、精密度和专属性 ,适用于硫酸阿奇霉素含量测定以及有关物质的概况分析  相似文献   

表征碳青霉烯类药物稳定性的指针性杂质的确定及其应用     

王楠  胡昌勤  刘茜 《药物分析杂志》2011,(1)

目的:采用自身降解物质作为定量指标,表征碳青霉烯类药物的降解程度,用以考察此类药物的稳定性和指针性杂质共性。方法:以美罗培南、亚胺培南和比阿培南为例,进行加速稳定性试验,寻找具有代表性的指针性杂质,并考察药物自身降解程度与指针性杂质之间的量值关系,用以作为稳定性表征指标。结果:HPLC法分析得到的美罗培南、亚胺培南和比阿培南主成分含量降低1.0%时的警戒线分别为:187,261,84。通过LC-MS确证指针性杂质结构为开环水解物。结论:通过对碳青霉烯类药物稳定性考察,依据指针性杂质表征降解程度。  相似文献   

反相高效液相色谱法测定注射用比阿培南聚合物杂质含量     

蔡洪鲲  孙国祥  胡玥珊 《中南药学》2011,9(12):904-906

目的 对注射用比阿培南聚合物进行定量检查,采用HPLC-TOF-MS法鉴别其聚合物.方法 用Century SIL C18 BDS (250 mm×4.6mm,5μm)色谱柱,流动相A为乙腈,B为0.01 mol·L-1碳酸氢铵溶液,洗脱程序:0～27 min,99％～70％B; 27～40 min,70％B,流速为1 mL·min-1,柱温(30±0.15)℃,检测波长220hm.采用自身对照法测定比阿培南聚合物的含量,并采用高效液相色谱飞行时间质谱(HPLC-TOF-MS)鉴定聚合物杂质.结果 自身对照法能准确测定比阿培南中聚合物含量,用液质联鉴定出含有2种聚合物.结论 采用高效液相色谱法和液质联用技术能对比阿培南聚合物杂质进行定性定量分析,方法简易准确可行.  相似文献   

液相色谱-质谱联用技术鉴定奥美沙坦酯有关物质   总被引：1，自引：0，他引：1  

王多娇  宋敏  杭太俊  孙德助 《药物分析杂志》2012,(1):82-87

目的:采用液相色谱-质谱联用技术对奥美沙坦酯中有关物质进行结构鉴定。方法:采用LiChrospher C8(250 mm×4.6 mm,5μm)色谱柱,以甲醇-醋酸铵缓冲液为流动相梯度洗脱,对奥美沙坦酯有关物质进行分离;采用LC-MS/MS电喷雾正离子化测定各有关物质的相对分子质量和二级质谱,并进行结构解析。结果:检测到奥美沙坦酯粗品中11个有关物质,并推测出它们的化学结构均为奥美沙坦母核结构未发生变化的不同取代咪唑和四氮唑联苯衍生物。结论:色谱-质谱联用技术能够有效地用于药物中有关物质的鉴定,奥美沙坦酯有关物质研究可为其质量控制和工艺优化提供参考依据。  相似文献