Involvement of lncR-30245 in Myocardial Infarction–Induced Cardiac Fibrosis Through Peroxisome Proliferator-Activated Receptor-γ–Mediated Connective Tissue Growth Factor Signalling Pathway     

Yuting Zhuang  Tingting Li  Yanan Zhuang  Zhuoyun Li  Wanqi Yang  Qihe Huang  Danyang Li  Hao Wu  Guiye Zhang  Ti Yang  Linfeng Zhan  Zhenwei Pan  Yanjie Lu 《The Canadian journal of cardiology》2019,35(4):480-489

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The Application of Number Needed to Treat (NNT) to Clinical Problems in Radiotherapy     

Ashesh B. Jani  Leon Myrianthopoulos  Srinivasan Vijayakumar 《Cancer investigation》2005,22(2):262-270

The goals of this report are: 1) to review the number needed to treat (NNT) concept, which, although well established in many sectors of medicine, is still relatively new to the radiotherapy community; 2) to discuss several clinical radiotherapy examples illustrating the inherent advantages of the NNT approach; and 3) to discuss potential future roles of the NNT concept within radiotherapy.  相似文献   

Report from the 1st Japanese Urological Association-Japanese Society of Medical Oncology joint conference, 2006: ''A step towards better collaboration between urologists and medical oncologists''     

Hideyuki Akaza 《International journal of urology》2007,14(5):375-383

The 1st Japanese Urological Association-Japanese Society of Medical Oncology Joint Conference, titled 'A step towards better collaboration between urologists and medical oncologists', was held to coincide with the 44th Meeting of the Japan Society of Clinical Oncology, Tokyo, in October 2006. The main theme of the conference addressed the need for a subspecialty of medical oncologist within urology to keep abreast of advances in medical oncology. Urologists should become more involved in the postoperative management of urologic cancer. Consensus on the optimal way to move forward in the treatment of urological cancer is needed. The conference featured eight lectures surveying the present status of uro-oncology in Europe, the USA, Korea, Singapore, and Japan; the relationship between surgical oncologists and medical oncologists; global trends and international clinical trials in uro-oncology; and the future of urologic oncology. These were followed by a general discussion titled 'Achieving better collaboration between the surgical oncologist and the medical oncologist.' This report presents a roundup of the 1st Japanese Urological Association-Japanese Society of Medical Oncology Joint Conference.  相似文献   

医学美学与美容医学的整体学科研究     

彭庆星  赵永耀  丁蕙孙  邱琳枝 《中国实用美容整形外科杂志》1997,(1)

回顾医学美学与美容医学形成独立的学科系统的十多年来的发展历程，认为这个新兴学科在“整体学科”方面还存在一些学术问题有待人们进一步探讨。并认为，所谓“整体学科研究”是遵循该学科发展的内在规律所进行的各项研究的总和，是该学科发展的灵魂。学者们的任务在于：通过“整体学科研究”寻求其学科内在规律，经一代代同道有志者坚持不懈的努力，达到学科完善的目的。  相似文献   

Lymphoma arising in an adenolymphoma   总被引：1，自引：0，他引：1  

G Hall  H Tesluk  S Baron 《Human pathology》1985,16(4):424-427

A malignant lymphoma that originated in association with an adenolymphoma (Warthin's tumor) of the parotid salivary gland is reported. The occurrence of lymphomas in salivary glands is discussed briefly.  相似文献   

Intimal changes associated with arterial spasm induced by periarterial application of calcium chloride     

A Kurgan  S D Gertz  R S Wajnberg 《Experimental and molecular pathology》1983,39(2):176-193

Arterial spasm was induced by application of calcium chloride to the adventitial surface of the rabbit common carotid artery in vivo. Sodium chloride (NaCl) was applied to the contralateral vessel as control. Vessels were fixed in situ by intravascular perfusion after 15 min, 1 hr, or 24 hr and prepared for light and scanning electron microscopy (SEM). With SEM, the luminal surface at the site of calcium application showed severe longitudinal folding accompanied by endothelial desquamation with extensive platelet deposition on exposed subendothelium. The luminal cross-sectional area was reduced by 53 +/- 19.5% after 15 min and by 44 +/- 12% after 1 hr as compared with the contralateral control. Furthermore, the luminal area at the site of calcium application was found to be reduced by 42 +/- 8% after 1 hr when compared with segments of the same vessel distal to the site of calcium application. Blood flow rate, as measured by electromagnetic flow probe, was not reduced. Vessels examined after 24 hr showed a significant increase in luminal cross-sectional area as compared with contralateral control vessels (136 +/- 70%). Control vessels (NaCl) showed no significant change in luminal cross-sectional area and no endothelial desquamation or platelet deposition after 15 min, 1 hr, or 24 hr. Examination of histologic sections showed calcium precipitation within the attached thrombus after 15 min with calcium deposits also adherent to the adjacent luminal aspect of the internal elastic lamina (IEL). By 24 hr, this precipitation extended throughout the media. Marked deposition of leukocytes was seen after 24 hr which showed a preferential attachment for areas of endothelial damage and discontinuity of IEL.  相似文献   

Does hyperimmunoglobulinemia-E protect tropical populations from allergic disease?   总被引：1，自引：0，他引：1  

J W Larrick  C E Buckley  C E Machamer  G D Schlagel  J A Yost  J Blessing-Moore  D Levy 《The Journal of allergy and clinical immunology》1983,71(2):184-188

The Waorani Indians of eastern Ecuador have the highest blood concentration of IgE reported in a human population. Evidence obtained by medical history, physical examination, and immediate hypersensitivity skin tests suggests that pollen allergy and other atopic diseases are rare among the Waorani. A similar association between parasite-induced hyperimmunoglobulinemia-E and a low prevalence of conventional atopic disease has been reported in numerous other tropical populations. Saturation of mast cell IgE receptors with antibodies directed to the parasite and/or other antigens and competitive inhibition of passive binding of pollen allergen-specific IgE is one hypothetical cause of this association. We have tested this interesting conjecture by passively sensitizing the skin of Waorani Indians with serum containing pollen allergen-specific IgE antibodies. Waorani Indians with hyperimmunoglobulinemia-E can be adoptively sensitized with human ragweed or rye grass hyperimmune IgE antisera. This suggests that the cutaneous mast cells of healthy Waorani have active IgE receptors. The high circulating plasma concentrations of IgE in the Waorani do not prevent adoptive cutaneous sensitization with pollen-specific IgE antibodies.  相似文献   

Translocation (6;9)(p23;q34) in acute nonlymphocytic leukemia: Three new cases     

Andrew J. Carroll  Robert P. Castleberry  Josef T. Prchal  Wayne H. Finley 《Cancer Genetics and Cytogenetics》1985,18(4):303-306

Several recent reports have described cases of acute nonlymphocytic leukemia with a unique chromosome translocation, t(6;9)(p23;q34). We have studied three additional patients who have acute nonlymphocytic leukemia and t(6;9)(p23;q34). Our findings provide additional support for the suggestion that this translocation is yet another distinct cytogenetic abnormality associated with myeloproliferative disorders.  相似文献   

Pathologic changes in the renal tubule in systemic lupus erythematosus     

Melvin M. Schwartz  John S. Fennell  Edmund J. Lewis 《Human pathology》1982,13(6):534-547

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Microemboli observed in deaths following cardiopulmonary bypass surgery: Silicone antifoam agents and polyvinyl chloridetubing as sources of emboli     

Jan Marc Orenstein  Noriko Sato  Benjamin Aaron  Bryan Buchholz  Sherman Bloom 《Human pathology》1982,13(12):1082-1090

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