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Moreno B Arroyo B Torres-González F de Dios Luna J Cervilla J 《Social psychiatry and psychiatric epidemiology》2007,42(6):452-456
Introduction Since community-based health care was introduced, the use of mental health services by patients with serious mental disorders
has been an issue of much interest. However, our knowledge of intervening factors is both scarce and partial.
Objective To study socio-demographic variables which may predict time-lapse (in days) between each out-patient contact among a cohort
of schizophrenia patients.
Method Data comes from the South Granada Schizophrenia Case Register. We used Cox’s regression analysis to study the influence of
the socio-demographic variables in the time lapsed between out-patient contacts.
Results After adjusting for all other socio-demographic variables included, we found that to live in a rural area and being younger
independently predicted a longer time-lapse between out-patient contacts while being retired predicted a shorter interval
between such contacts. Other variables such as sex, educational level and marital status did not determine such length between
out-patients contacts.
Conclusion Socio-demographic variables, and not only psychopathological ones, determine mental health out-patient service use. 相似文献
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目的了解佛山市顺德区重性精神疾病患者的肇事肇祸等情况。方法对登记在册的4107例重性精神疾病患者进行一般信息统计和基础情况调查，评估其危险性，了解其肇事肇祸情况。结果4107例重性精神疾病患者中，肇事肇祸患者共962例（23％），肇事肇祸患者以精神分裂症（62％）最多见，并且具有男性（63．7％）为多、未婚和丧偶较多、经济状况较差、服药依从性差和阳性家族史较多的特点。结论要重视重性精神疾病患者的药物治疗，并建立有效的社区干预模式。 相似文献
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目的:对山东日照地区重性精神疾病患者管理治疗状况和肇事肇祸情况进行调查分析。方法:对日照市城乡部分登记在册的重性精神疾病患者进行疾病分类管理并对肇事肇祸情况进行危险性评估。结果:重性精神疾病患者中未治疗的患者占26.34%、门诊治疗的患者占34.31%,住院治疗的患者占39.35%。患者中肇事肇祸发生率为82.37%,其中精神分裂症患者肇事肇祸最多。危险性评估为高风险患者占53.30%。结论:重性精神疾病患者治疗不足,肇事肇祸发生多,应该加强这一特殊人群的管理和治疗。 相似文献
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目的:了解南宁市兴宁区重性精神疾病患者肇事肇祸情况及危险因素。方法:对登记在册的兴宁区712例重性精神疾病患者进行危险性评估,了解其有无肇事肇祸情况。结果:712例重性精神疾病患者中有肇事肇祸患者148例,占20.79%,其中精神分裂症患者中最多,占20.96%;肇事肇祸的发生与患者的性别、婚姻、家族史、服药依从性等原因有关。结论:需要针对高危的社区重性精神疾病患者加强监管和治疗。 相似文献
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Hope S Dieset I Agartz I Steen NE Ueland T Melle I Aukrust P Andreassen OA 《Journal of psychiatric research》2011,45(12):1608-1616
Objective
Elevated levels of inflammation are reported in bipolar disorders (BP), but how this relates to affective symptoms is unclear. We aimed to determine if immune markers that consistently have been reported elevated in BP were associated with depressive and manic symptoms, and if this was specific for BP.Methods
From a catchment area, 112 BP patients were included together with 153 schizophrenia (SCZ) patients and 239 healthy controls. Depression and mania were assessed and the patients were grouped into depressed, neutral, and elevated mood. We measured the immune markers tumor necrosis factor receptor 1 (sTNF-R1), interleukin 1 receptor antagonist (IL-1Ra), interleukin 6 (IL-6), high sensitive C-reactive protein (hsCRP), osteoprotegerin (OPG) and von Willebrand factor (vWf) which have been found increased in severe mental disorders.Results
In BP all inflammatory markers were lowest in depressed state, with significant group differences after control for confounders with respect to TNF-R1 (p = 0.04), IL-1Ra (p = 0.02), OPG (p = 0.004) and IL-6 (p = 0.005). STNF-R1 was positively correlated with the item elevated mood (p = 0.02) whereas sad mood was negatively correlated with OPG (p = 0.0003), IL-1Ra (p = 0.001) and IL-6 (p = 0.006). Compared to controls the neutral mood group had significantly higher levels of OPG (p = 0.0003) and IL-6 (p = 0.005), and the elevated mood group had higher levels of TNF-R1 (p = 0.000005) and vWf (p = 0.002). There were no significant associations between affective states orsymptoms in SCZ.Conclusions
The current associations between inflammatory markers and affective symptomatology in BP and not SCZ suggest that immune related mechanisms are associated with core psychopathology of BP. 相似文献6.
Nils Eiel Steen Martin Tesli Anna K. Khler Paal Methlie Sigrun Hope Elizabeth A. Barrett Sara Larsson Erlend Mork Kristian Lvs Jan Ivar Rssberg Ingrid Agartz Ingrid Melle Srdjan Djurovic Steinar Lorentzen Jens P. Berg Ole A. Andreassen 《Progress in neuro-psychopharmacology & biological psychiatry》2010,34(8):375-1506
Objective
Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is documented in bipolar disorder and schizophrenia, but the mechanism is unclear; recently, increased activity of cortisol metabolizing enzymes was indicated in these disorders. We investigated whether five genes involved in cortisol metabolism were associated with altered activity of cortisol metabolizing enzymes in bipolar disorder (BD) and schizophrenia spectrum disorders (SCZ).Methods
A case–control sample of subjects with BD (N = 213), SCZ (N = 274) and healthy controls (N = 370) from Oslo, Norway, were included and genotyped from 2003 to 2008. A sub-sample (healthy controls: N = 151; SCZ: N = 40; BD: N = 39) had estimated enzyme activities based on measurements of urinary free cortisol, urinary free cortisone and metabolites. A total of 102 single nucleotide polymorphisms (SNPs) in the SRD5A1, SRD5A2, AKR1D1, HSD11B1 and HSD11B2 genes were genotyped, and significant SNPs analyzed in the sub-sample.Results
There was a significant association of rs6732223 in SRD5A2 (5α-reductase) with SCZ (p = 0.0043, Bonferroni corrected p = 0.030, T risk allele). There was a significantly increased 5α-reductase activity associated with rs6732223 (T allele) within the SCZ group (p = 0.011).Conclusions
The present data suggest an interaction between SCZ and SRD5A2 variants coding for the enzyme 5α-reductase, giving rise to increased 5α-reductase activity in SCZ. The findings may have implications for cortisol metabolizing enzymes as possible drug targets. 相似文献7.
目的：了解农村重性精神疾病患者肇事肇祸情况。方法：从已登记的1427例农村重性精神疾病患者中调查有无肇事肇祸情况。结果：1427例中有肇事肇祸患者308例（21.6%）,其中以精神分裂症最多1067例（74.8%）。肇事肇祸的发生率与患者的性别、文化程度、诊断、监护人、病程、住院次数和服药依从性等有关。结论：对农村重性精神疾病患者的监护和治疗工作应引起充分重视。 相似文献
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Sigrun Hope Ingrid Melle Pål Aukrust Nils Eiel Steen Astrid B Birkenaes Steinar Lorentzen Ingrid Agartz Thor Ueland Ole A Andreassen 《Bipolar disorders》2009,11(7):726-734
Background: Alterations in the inflammatory system have been associated with schizophrenia and major depression, while bipolar disorder has been less studied. Most previous studies examined small samples, and the literature is inconsistent with regard to specific underlying immune mechanisms. In the present study, we examined markers representing different inflammatory pathways, and the aim was to investigate whether the levels of inflammatory parameters in a representative sample of bipolar disorder and schizophrenia are elevated compared to healthy controls, and to investigate whether the inflammatory profile is different between the groups.
Methods: Plasma levels of soluble tumor necrosis factor receptor 1 (sTNF-R1), interleukin-1 receptor antagonist (IL-1Ra), interleukin-6 (IL-6), high-sensitivity CRP (hs-CRP), soluble CD40L ligand (sCD40L), and von Willebrand factor (vWf) were measured with ELISA techniques in a catchment area based sample of consecutively referred patients with severe mental disorders [N = 311, comprising bipolar disorder (n = 125) and schizophrenia (n = 186)] and in healthy volunteers (n = 244).
Results: Plasma levels of sTNF-R1 and vWf were statistically significantly increased in both bipolar disorder and schizophrenia compared to controls (p < 0.00001), and were also increased in unmedicated patients, but there were no major differences between the two diagnostic groups. Controlling for age, gender, ethnicity, cardiovascular disorders, kidney and liver function, and other confounders did not affect the results. There were no differences in other inflammation factors between the groups.
Conclusion: The present results indicate specific alterations of endothelium-related inflammation processes in both bipolar disorder and schizophrenia. 相似文献
Methods: Plasma levels of soluble tumor necrosis factor receptor 1 (sTNF-R1), interleukin-1 receptor antagonist (IL-1Ra), interleukin-6 (IL-6), high-sensitivity CRP (hs-CRP), soluble CD40L ligand (sCD40L), and von Willebrand factor (vWf) were measured with ELISA techniques in a catchment area based sample of consecutively referred patients with severe mental disorders [N = 311, comprising bipolar disorder (n = 125) and schizophrenia (n = 186)] and in healthy volunteers (n = 244).
Results: Plasma levels of sTNF-R1 and vWf were statistically significantly increased in both bipolar disorder and schizophrenia compared to controls (p < 0.00001), and were also increased in unmedicated patients, but there were no major differences between the two diagnostic groups. Controlling for age, gender, ethnicity, cardiovascular disorders, kidney and liver function, and other confounders did not affect the results. There were no differences in other inflammation factors between the groups.
Conclusion: The present results indicate specific alterations of endothelium-related inflammation processes in both bipolar disorder and schizophrenia. 相似文献
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