Neurocysticercosis immunodiagnosis using Taenia solium cysticerci crude soluble extract, excretory secretory and lower molecular mass antigens in serum and urine samples of Indian children     

Subba Rao V. Atluri  N. Malla 《Acta tropica》2009,110(1):22-1297

Neurocysticercosis (NCC), the most common neurological disorder of parasite etiology, results from lodgment of Taenia solium cysticerci in the central nervous system and is now increasingly being recognized in children. The confirmed diagnosis is based collectively on radiological findings and serodiagnostic techniques. The serodiagnostic techniques have variable sensitivity and specificity depending upon the technique, antigens used, location and number of cysts. Crude soluble extract (CSE), excretory secretory (ES) and lower molecular mass (LMM) (10-30 kDa) antigenic fraction of T. solium cysticerci were evaluated for antibody detection in serum and urine samples by ELISA. Serum and urine samples were collected each from 125 clinically suspected and radiologically proven NCC (111 with single Computed Tomography (CT) lesions and 14 with multiple CT lesions) and 125 control subjects (60 with neurological disorders other than NCC, 40 with other parasitic diseases and 25 apparently healthy subjects). The sensitivity of the ELISA with the use of CSE, ES and LMM antigenic fractions was 38.4%, 63.2% and 30.4% with serum (cut off dilution 400), 46.4%, 44% and 47.2% with neat urine and the specificity was 88%, 76.8% and 85.6% with serum (cut off dilution 400), 66.4%, 65.2% and 58.4% with neat urine samples, respectively. The study suggests that detection of antibody to ES antigen in serum samples may serve useful purpose for the serodiagnosis of human NCC.  相似文献   

NEUROCYSTICERCOSIS IN CHILDREN PRESENTING WITH AFEBRILE SEIZURE: CLINICAL PROFILE,IMAGING AND SERODIAGNOSIS     

Priyadarshi Soumyaranjan Sahu  Jyotsna Seepana  Sudarsini Padela  Abani Kanta Sahu  Swarna Subbarayudu  Ankur Barua 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(3):253-258

Neurocysticercosis (NCC) is one of the major causes of childhood seizuresin developing countries including India and Latin America. In this study neurologicalpediatric cases presenting with afebrile seizures were screened for anti-Cysticercusantibodies (IgG) in their sera in order to estimate the possible burden ofcysticercal etiology. The study included a total of 61 pediatric afebrile seizuresubjects (aged one to 15 years old); there was a male predominance. All the sera weretested using a pre-evaluated commercially procured IgG-ELISA kit (UB-MagiwellCysticercosis Kit ^™). Anti-Cysticercus antibody in serum was positive in 23 of 61 (37.7%)cases. The majority of cases with a positive ELISA test presented with generalizedseizure (52.17%), followed by complex partial seizure (26.08%), and simple partialseizure (21.73%). Headaches were the major complaint (73.91%). Other presentationswere vomiting (47.82%), pallor (34.78%), altered sensorium (26.08%), and muscleweakness (13.04%). There was one hemiparesis case diagnosed to be NCC. In this studyone child without any significant findings on imaging was also found to be positiveby serology. There was a statistically significant association found between thecases with multiple lesions on the brain and the ELISA-positivity (p= 0.017). Overall positivity of the ELISA showed a potential cysticercal etiology.Hence, neurocysticercosis should be suspected in every child presenting with afebrileseizure especially with a radio-imaging supportive diagnosis in tropical developingcountries or areas endemic for taeniasis/cysticercosis.  相似文献   

    

《Epilepsy research》2014,108(7):1212-1220

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Antonio Fernndez-Bouzas  Thalía Harmony  Thalía Fernndez  Josefina Ricardo-Garcell  Gustavo Casin  Raul Snchez-Conde 《Clinical neurophysiology》2001,112(12):2281-2287

OBJECTIVES: To compare two different functional procedures in the assessment of brain ischemia in patients with neurocysticercosis (NCC): (1) electroencephalography (EEG) evaluated by brain maps and EEG current sources in the frequency domain using variable resolution electromagnetic tomography and (2) blood flow analyzed by computerized tomography assessed with stable Xe (Xe-CT). METHODS: Eleven patients with NCC at different evolution stages were studied. CT and Xe-CT scans, as well as quantitative electroencephalography with source calculation in the frequency domain, were obtained. All patients showed cysts and in 6 of them there were also vascular complications: two of them presented calcifications of the middle cerebral artery, two other subjects showed calcifications of the vessels in the circle of Willis and the remaining two had brain infarctions. RESULTS: In the cyst areas important hypoperfused zones were observed, as intense as those observed in infarcted areas. Damage to the blood-brain barrier was originated by parasites in colloidal phase (final cysticerci stage) producing large areas of edema and hypoperfusion. Abnormal delta EEG activity was observed in very large lesions, probably generated by partial cortical deafferentation; and abnormal theta activity was mainly related to the presence of edema. CONCLUSIONS: Sources of abnormal EEG activity were very similar in topography to the hypoperfused areas.  相似文献   

脑猪囊尾蚴病临床及病理学特点   总被引：1，自引：0，他引：1  

郑金锋  马淑芳  耿明  景洪标  曹永成  孙希炎 《中国临床神经外科杂志》2012,17(1):21-23

目的 探讨脑猪囊尾蚴病的临床及病理学特点.方法 回顾性分析13例脑猪囊尾蚴病患者的临床资料,并结合文献对其影像学、病理学进行分析.结果 本组13例患者中,11例以癫痫发作为主要症状;6例病理学检查均发现囊尾蚴虫体;9例病灶周围脑组织可见炎症反应;在病灶及其周围的脑组织中可见散在的石灰小体.头部CT检查表现为片状或点状低密度影,病灶区MRI表现为囊性异常信号.结论 脑猪囊尾蚴病首发症状以癫痫发作多见;影像学检查对脑猪囊尾蚴病诊断有帮助,但最后确诊需病理学检查;病理学检查除找到囊尾蚴虫体外,脑组织中发现散在的石灰小体是诊断陈旧性病变的重要依据.  相似文献   

应用神经内镜手术治疗脑囊虫   总被引：20，自引：2，他引：20  

高鲜红  张亚卓  刘丕楠  王忠诚 《中华神经外科杂志》2001,17(4):214-216

目的：探讨应用神经内镜治疗脑囊虫的方法和意义。方法：应用神经内镜探查、冲洗、摘除脑囊虫。结果：10例脑室内囊虫,2例脑实质囊虫（形成囊性占位效应）摘除,2例行脑室－腹腔分流。14例均疗效满意。无明显并发症。结论：用神经内镜治疗服囊虫具有安全、高效、并发症少的优势。  相似文献   

脑囊尾蚴病的病理改变及分期     

徐安健  谷俊朝 《国际医学寄生虫病杂志》2010,37(6)

近些年,由于显微技术和影像学技术的广泛应用以及脑囊尾蚴病的高发病率引起人们的高度重视,越来越多的人关注于其发病机制及病理变化,而关于脑囊尾蚴病的分型及分期各文献报道却不一致,该文针对其病理改变及分型分期作一综述.  相似文献   

脑囊尾蚴病神经影像学表现与循环抗原相关性研究     

冯伟  张新定  原睿智  韩彦明  周旺宁  程得均 《神经疾病与精神卫生》2008,8(3):176-178

目的探讨脑囊虫病血清循环抗原（CAg）与神经影像学（CT、MRI）的关系。方法根据诊断脑囊虫病的四个标准,对确诊的36例脑囊虫病病人行CAg定量测定及神经影像学检查并分期。结果根据神经影像学检查,36例脑囊虫病人在活虫期、变性死亡早期、变性死亡后期及钙化期之间的CAg水平有显著性差异（P〈0.01）。相关性分析表明血清中CAg的含量与脑囊虫病的神经影像学表现具有正相关性,其相关系数为0.871。结论（1）脑囊虫病人循环抗原与神经影像学（CT、MRI）表现具有相关性;（2）血清循环抗原的检查可用于对脑囊虫病的早期诊断和指导临床治疗。  相似文献   

CT脑室造影对脑室型囊尾蚴病的诊断价值     

王燕冰  姚鹏鹏  王军委  张钧  陈洁  李师佳  周志霞  贾玉昌  张霞 《医药论坛杂志》2009,30(9):19-20

目的评价CT脑室造影的方法及价值,为手术摘除囊尾蚴提供理论依据。方法回顾性分析30例经手术病理证实的脑室内囊尾蚴病的CT脑室造影表现。通过脑室引流管注入2ml非离子造影剂行CT扫描。结果四脑室充盈缺损20例,三脑室3例,侧脑室7例。合并脑实质型13例,合并脑膜型7例。结论CT脑室造影方法简单,安全,实用,是CT、MRI重要的补充检查手段。  相似文献   

不典型脑膜型脑囊虫病一例     

汪丹凤;刘恺;彭旭红;张雪林 《磁共振成像》2012,3(01):54-55

患者,男,27岁,因\"双下肢无力10月,伴头痛、头晕7月,加重1月余\"入院。查体：双下肢肌肉萎缩,左下肢肌力3级,右下肢肌力2级,L₂水平以下痛觉减退,双侧直腿抬高试验阳性,双侧膝腱反射及跟腱反射消失。脑膜刺激征阳性。  相似文献