Excessive iron storage in a patient with Wilson's disease     

P. Hafkemeyer  M. Schupp  M. Storch  W. Gerok  D. Hässinger 《Journal of molecular medicine (Berlin, Germany)》1994,72(2):134-136

We report on an otherwise healthy female, mother of two children, with severe decompensated liver cirrhosis due to an iron overload and Wilson's disease. The patient was considered heterozygote for hemochromatosis on the basis of the autosomal recessive inheritance for hemochromatosis, the frequency of the hemochromatosis gene, and the laboratory parameters defining her iron overload. The case is interesting because of the coincidence of Wilson's disease and excessive iron storage. Correspondence to: D. Haussinger  相似文献   

西宁地区冠心病患者血浆铁蛋白血脂水平测定的意义     

张亚萍  连新龙 《高原医学杂志》2004,14(4):19-20

目的 :探讨血浆铁蛋白及血脂水平在西宁地区冠心病诊治中的价值。方法 :西宁地区经临床确诊的冠心病患者 6 5例 ,其中冠心病合并高血压 30例 ,采清晨空腹静脉血 5ml,应用日立7170s全自动生化仪测定血浆铁蛋白、血脂 (TCh、TG、HDL -c、LDL -c)。 30例健康查体者为对照组。结果 :本地区冠心病患者血浆铁蛋白水平较对照组明显降低 (P <0 .0 1) ,LDL -C水平较对照组增高 (P <0 .0 5 )。结论 :高海拔地区冠心病患者血浆铁蛋白浓度显著低于正常对照组。较低的铁蛋白水平提示存在着较高的血清游离铁水平 ,促进了LDL的脂质氧化 ,加快了动脉粥样硬化斑块的形成  相似文献   

Are Current Serum and Plasma Ferritin Cut-offs for Iron Deficiency and Overload Accurate and Reflecting Iron Status? A Systematic Review     

Maria Nieves Garcia-Casal  Sant-Rayn Pasricha  Ricardo X. Martinez  Lucero Lopez-Perez  Juan Pablo Peña-Rosas 《Archives of medical research》2018,49(6):405-417

  相似文献   

铁超负荷与Ⅱ型糖尿病关系的研究     

胡凯  刘俊峰  鞠萍 《中国热带医学》2007,7(2):246-247

目的探讨铁超负荷与Ⅱ型糖尿病（Diabetes Mellitus，DM）之间的关系。方法采用放射免疫方法测定血清中的铁蛋白（Serum Ferritin，SF）和胰岛素（INS）含量，用全自动生化分析仪测定血清铁（Serum Iron，SI）和血糖的浓度。结果与对照组相比，Ⅱ型糖尿病患者SF水平和胰岛素抵抗指数（Homeostasis Model Assessment-Insulin Resistatice，HOMA—IR）显著升高（P〈0．01）。结论Ⅱ型糖尿病存在铁超负荷，造成IR。铁超负荷可能是Ⅱ型糖尿病的一种重要风险因子。  相似文献   

Distribution of ferritin in the rat hippocampus after kainate-induced neuronal injury     

Huang E  Ong WY 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2005,161(4):502-511

A gradual increase in iron occurs in the lesioned hippocampus after neuronal injury induced by the excitotoxin kainate, and the present study was carried out to investigate whether this increase in iron might be associated with changes in expression of the iron binding protein, ferritin. An increase in ferritin immunoreactivity was observed in glial cells of the hippocampus, as early as three days after intracerebroventricular injections of kainate. The number of ferritin positive cells peaked four weeks after the kainate injection, and decreased eight and twelve weeks after injection. They were found to be mostly microglia and oligodendrocytes by double immunofluorescence labeling with glial markers. A number of ferritin-labeled endothelial cells were also observed via electron microscopy. The decline in ferritin immunoreactivity four weeks after the injection of kainate is accompanied by an increase in the number of ferric and ferrous iron positive cells in the lesioned tissue. A substantial non-overlap between ferritin and iron-containing cells was observed. In particular, spherical ferric or ferrous iron-laden cells in the degenerating hippocampus were unlabeled for ferritin for long time periods after the kainate injection. An increase in iron, together with a reduced expression of iron binding proteins such as ferritin at long time intervals after kainate lesions, could result in a relative decrease in ferritin-induced ferroxidase activity and the presence of some of the iron in the ferrous form. It is postulated that this may contribute to chronic neuronal injury, following acute kainate-induced neurodegeneration.  相似文献   

血液透析患者血清SF、TSAT水平与营养状况的相关性分析     

李梅  黄楠  陈曦 《标记免疫分析与临床》2019,26(4):625-628

目的分析维持性血液透析(MHD)患者血清铁蛋白(SF)、转铁蛋白饱和度(TSAT)水平与营养状况的关系。方法选取MHD患者92例(MHD组)和健康体检者50例(对照组),所有受试对象均完成营养状况评估[改良主观综合营养评估法(MQSGA)]、营养生化指标检测[血清白蛋白(Alb)、血红蛋白(Hb)],并行血清SF、TSAT测定。根据MQSGA评分将MHD组进一步分为重度营养不良亚组、轻中度营养不良亚组、营养正常亚组。结果相较于对照组,MHD组BMI、TSF、MAC、HGS及血清A1b、血清Hb均明显降低(P <0.05),MQSGA评分明显增高(P <0.05)。MHD组血清SF明显高于对照组(P <0.05), TSAT明显低于对照组(P <0.05)。MHD患者不同营养状况亚组血清SF、TSAT水平比较差异有统计学意义(P <0. 05),随着营养不良状况越严重,患者血清SF逐渐增高(P <0. 05),TSAT逐渐降低(P <0.05)。相关性分析显示,MHD患者MQSGA评分与血清SF水平呈正相关(r=0.468,P<0.05),与TSAT水平呈负相关(r=-0.394,P<0. 05)。结论 MHD患者血清SF明显增高,TSAT明显降低,血清SF、TSAT水平可能与MHD患者营养不良相关。  相似文献   

    

Junxin Yan  Tongjuan Guan  Meiqi Guo  Jingfang Liu 《The Turkish journal of gastroenterology》2023,34(9):952

  相似文献   

sCD163和铁蛋白在HBV相关慢加急性肝功能衰竭中的表达及其临床意义     

李珊珊  李璐  张丹丹  仵永枫  丁美  段钟平  陈煜 《肝脏》2014,(10):733-735

目的：研究 HBV相关慢加急性肝功能衰竭（HBV-ACLF）患者血浆中可溶性 CD163（sCD163）和铁蛋白水平,分析其与患者病情、预后的关系。方法选择HBV-ACLF患者30例、乙型肝炎肝硬化25例、慢性乙型肝炎18例以及健康对照15例,采用ELISA方法检测血浆中 sCD163和铁蛋白水平。结果 HBV-ACLF 组血浆中 sCD163和铁蛋白水平均明显高于肝硬化组、慢性乙型肝炎组及健康对照组[sCD163：（123±43）比（76±33）、（58±19）、（35±15）ng/mL,均P＜0．05;铁蛋白：（2714±1896）比（505±722）、（833±801）、（106±58）ng/mL,均P＜0．05]。肝衰竭发展到晚期时sCD163和铁蛋白水平均较早、中期明显增高[sCD163：（162±44）比（104±40）、（108±24）ng/mL,均P＜0．05）;铁蛋白：（4154±2122）比（1746±1047）、（2416±1713）ng/mL,均P＜0．05]。HBV-ACLF死亡组中sCD163和铁蛋白水平均高于存活组[sCD163：（140±42）比（101±36）mg/mL,（t＝-2．719,P＝0．01）;铁蛋白：（3568±2007）比（1598±957）ng/mL,（t＝-3．547,P＝0．001）]。经受试者工作特征曲线（ROC）分析,sCD163、铁蛋白评估 HBV-ACLF患者3个月内死亡所对应的曲线下面积（AUC）分别为0．803、0．844。结论 sCD163和铁蛋白可作为 HBV-ACLF病情严重程度及预后评估的重要参考指标。  相似文献   

低铁环境对去势小鼠血清骨钙素及骨组织影响的初步研究     

高超  施勤  贾鹏  张增利  徐又佳 《中华内分泌代谢杂志》2012,28(12):967-971

目的 观察去势小鼠在低铁环境下血清骨钙素及骨微结构的变化.方法 24只12周龄C57BL/6小鼠,体重(19.5±0.5)g分为假手术组(SHAM)、模型组(OVX)、低铁组(OVX+DFO),每组8只.低铁组于卵巢切除后第2天腹腔注射甲磺酸去铁胺(DFO),剂量为30 mg/kg,每周3次,共5周;模型组、假手术组均腹腔注射同等刹量0.9％生理盐水,共5周;第5 周末取血后处死小鼠并分离子宫、左侧股骨;ELISA试剂盒检测血清骨钙素、血清铁蛋白;分析天平称子宫重量;显微CT扫描股骨末端并取目标区进行三维重建,获取骨小梁、骨皮质三维结构图像,进行松质骨、皮质骨定量分析.结果 (1)血清骨钙素、血清铁蛋白:低铁组均显著低于模型组、假手术组(P＜0.01);(2)松质骨、皮质骨骨密度:低铁组均显著低于模型组、假手术组(P＜0.01),骨小梁厚度、骨小梁间隔低铁组显著增加(P＜0.01),骨小梁数量、骨体积分数低铁组显著降低(P＜0.01).结论 一定剂量的DFO(30 mg/kg)可以降低去势小鼠血清铁蛋白水平和骨组织形成指标.  相似文献   

Serum ferritin level as a marker of disease activity and renal involvement in Egyptian children with juvenile systemic lupus erythematosus     

Samia Salah-El-Din Mahmoud  Doaa Ghaith  Yomna Farag  Bishoy Ibrahim 《The Egyptian Rheumatologist》2018,40(4):273-276

Introduction

Ferritin is an acute-phase reactant that is elevated in several autoimmune disorders. Serum ferritin levels have been correlated with disease activity scores of juvenile systemic lupus erythematosus (JSLE). Furthermore, enhanced levels of ferritin have also been described in lupus nephritis (LN).

Aim of the work

To evaluate serum ferritin as a cheap and available marker of disease activity and renal involvement in Egyptian children with JSLE.

Patients and methods

Forty-eight JSLE cases recruited from the Pediatric Rheumatology Clinic in Cairo University Specialized Children’s Hospital and 43 matched healthy children were enrolled in the study. SLE disease activity score-2000 (SLEDAI-2K) and renal activity score were assessed. Serum levels of ferritin, was quantified by enzyme-linked immunosorbent assay.

Results

The mean age of the patients was 12.6?±?3.02?years and disease duration 3.4?±?2.5?years. Serum ferritin significantly higher in patients (416.1?±?1022.9?ng/ml) compared with control (36.1?±?18.2?ng/ml) (p?<?0.001). Serum ferritin was significantly higher in active (n?=?20) (890.4?±?1474.8?ng/ml) compared to inactive (n?=?28) (77.4?±?74.1?ng/ml) patients (p?<?0.001). A significant correlation was found between serum ferritin with SLEDAI-2K (r?=?0.35, p?=?0.014), renal-SLEDAI-2K (r?=?0.49, p?<?0.001) and with renal activity score (r?=?0.38, p?=?0.008). A significant correlation was found between serum ferritin and anti-double stranded-DNA (r?=?0.44, p?=?0.002) and complement 3 (r?=??0.42, p?=?0.003).

Conclusion

Serum ferritin level can be considered a reliable biomarker for monitoring disease and renal activity in children with JSLE and LN. This may lead to improvement of management and consequently prognosis of JSLE patients as serum ferritin is an available and relatively cheap marker.  相似文献