首页 | 官方网站   微博 | 高级检索  
     

冬虫夏草软胶囊改善支气管哮喘患者气道炎症的临床研究
引用本文:王宁群,姜良铎,张晓梅,李宗信.冬虫夏草软胶囊改善支气管哮喘患者气道炎症的临床研究[J].中国中药杂志,2007,32(15):1566-1568.
作者姓名:王宁群  姜良铎  张晓梅  李宗信
作者单位:1. 首都医科大学,宣武医院,中医科,北京,100053
2. 北京中医药大学,东直门医院,北京,100700
3. 北京中医药大学,东方医院,北京,100078
摘    要:目的:观察冬虫夏草软胶囊对支气管哮喘患者气道炎症的改善作用,探索中医补益肺肾法对哮喘患者治疗作用的相关机制。方法:将60例符合纳入标准的支气管哮喘患者随机分为治疗组(30例)和对照组(30例)。对照组以吸入激素+短效支气管扩张剂治疗,治疗组在此治疗的基础上加用冬虫夏草软胶囊。疗程2个月。检测治疗前后患者血清中的相关炎症指标IL-4,IFN-γ,sICAM-1,MMP-9,IgG,IgE。结果:治疗组治疗后血清IgG升高,IgE,sICAM-1,IL-4,MMP-9明显降低。两组间比较,治疗组对IgE,sICAM-1,IL-4,MMP-9的改善优于对照组(P<0.05,P<0.01)。对IgG,IFN-γ的改善两组间差别未产生统计学意义。结论:冬虫夏草软胶囊可能通过调节TH1/TH2的平衡,减少IL-4的分泌,降低黏附分子的表达,抑制炎性细胞的黏附和跨内膜转移,减少IgE合成,从而减轻气道炎症,缓解哮喘症状。该药物还可能具有一定的改善气道重构的作用。

关 键 词:冬虫夏草软胶囊  支气管哮喘  气道炎症
文章编号:1001-5302(2007)15-1566-03
收稿时间:1/8/2007 12:00:00 AM
修稿时间:2007-01-08

Effect of Dongchong Xiacao capsule on airway inflammation of asthmatic patients
WANG Ning-qun; JIANG Liang-duo; ZHANG Xiao-mei; LI Zong-xin.Effect of Dongchong Xiacao capsule on airway inflammation of asthmatic patients[J].China Journal of Chinese Materia Medica,2007,32(15):1566-1568.
Authors:WANG Ning-qun; JIANG Liang-duo; ZHANG Xiao-mei; LI Zong-xin
Affiliation:1. Department of Traditional Chinese Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; 2. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; 3. Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
Abstract:OBJECTIVE: To investigate the effect of dongchong xiacao capsule on the airway inflammation of asthmatic patients and to explore the relevant mechanism of therapeutic effect of Dongchongxiacao capsule. METHOD: Sixty patients with moderate persistent asthma were randomized into the treatment group (n=30) and the control group (n=30). Inhaled corticosteroid and as-needed beta-agonist were used in the treatment group while this therapy plus dongchong xiacao capsule were used in the control group for two months. Serum IL-4, IFN-gamma, sICAM-1, MMP-9, IgG, IgE level were assessed at randomization and 2 months after randomization. RESULT: The serum level of IgE, sICAM-1, IL-4 and MMP-9 of the treatment group was lowered to a greater degree than that of the control group (P < 0.05 or P < 0.01 ). CONCLUSION: Dongchong xiacao capsule can reduce the serum markers of airway inflammation, which suggests this therapy bares the anti-inflammation effects probably through regulating the balance of TH1/TH2, inhibiting the activity of adherence molecule and reducing IgE production. It may also have the effect of reversing airway remodeling, which needs further research to determine.
Keywords:Dongchong Xiacao capsule  bronchial asthma  airway inflammation
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司    京ICP备09084417号-23

京公网安备 11010802026262号